Can I take 2 aspirins at once? Because aspirin has some anti-blood-clotting capabilities, some doctors may recommend taking either 81 or 325 mg of aspirin per day if you’ve had or are at risk for certain conditions. If you have pain or a fever, you’ll usually take one to two pills at 325 or 500 mg every four to six hours. How much aspirin is too much? A toxic dose of aspirin is 200 to...